Wittenberg C, Rosenfeld J B
Harefuah. 1989 Feb 1;116(3):135-7.
Antihypertensive medication was stopped in 20 patients with mild hypertension who had no signs of left ventricular hypertrophy and in whom fundoscopy was normal. At the end of 12 and 24 months, 60% and 34%, respectively, had remained normotensive. In 2 patients therapy had to be reinstituted after 1 year, and in 1 after 2 years. 8 had decided by themselves to restart treatment even though their blood pressures were in the normal range. 3 were uncooperative and dropped out of the study. These results show that a large proportion of mild hypertensives remain normotensive long after withdrawal of drug therapy. Since in our experience temporary withdrawal is beneficial, we suggest that therapy be stopped when mild hypertension has been controlled for at least 2 years. However, there must be careful followup and therapy should be reinstituted at once if hypertension recurs.
20例轻度高血压患者停用了降压药物，这些患者无左心室肥厚体征且眼底检查正常。在12个月和24个月结束时，分别有60%和34%的患者血压仍保持正常。有2例患者在1年后不得不重新开始治疗，1例在2年后重新开始治疗。8例患者尽管血压在正常范围内，但自行决定重新开始治疗。3例患者不合作，退出了研究。这些结果表明，很大一部分轻度高血压患者在停药后很长时间内血压仍保持正常。鉴于我们的经验，暂时停药是有益的，我们建议在轻度高血压得到控制至少2年后停药。然而，必须进行仔细的随访，如果高血压复发，应立即重新开始治疗。
