Jennings G L, Reid C M, Sudhir K, Laufer E, Korner P I
Alfred and Baker Medical Unit, Alfred Hospital, Melbourne, Australia.
Blood Press Suppl. 1995;2:99-107.
We have reviewed the literature on the effect of withdrawal of antihypertensive therapy on return to hypertension. We also present our data from 83 patients in whom a 12-month follow-up period showed that 28% required re-institution of therapy within 10 weeks of withdrawal of medication, over half by 20 weeks, but a significant proportion (28%) stayed normotensive off therapy for a year. All patients had met the criteria for resumption of antihypertensive medication after 2 years of therapy. We also demonstrated predictive effects of left ventricular hypertrophy and duration of therapy on rate of redevelopment of hypertension. Our study raises the possibility that echocardiography may indicate the likelihood of a rapid return to hypertension when drug therapy is ceased.
我们回顾了关于停用抗高血压治疗后血压恢复情况的文献。我们还展示了来自83例患者的数据，在为期12个月的随访期内，这些患者中有28%在停药后10周内需要重新开始治疗，超过半数在20周内需要重新治疗，但仍有相当比例（28%）在停药后一年血压保持正常。所有患者在接受两年治疗后均符合重新开始抗高血压药物治疗的标准。我们还证明了左心室肥厚和治疗持续时间对高血压复发率的预测作用。我们的研究提出了一种可能性，即超声心动图可能预示着停药后血压迅速恢复至高血压水平的可能性。
