He Ye, Wu Huan, He Xiaojin, Xing Qiong, Zhou Ping, Cao Yunxia, Wei Zhaolian
a Reproductive Medicine Center, The First Affiliated Hospital of Anhui Medical University , Hefei , China.
Gynecol Endocrinol. 2016 Oct;32(10):811-815. doi: 10.1080/09513590.2016.1180680. Epub 2016 May 5.
This prospective cohort study aimed to examine the effects of atosiban, given before transfer of frozen-thawed embryo to women with different number of embryo transfer (ET) cycles. Atosiban treatment significantly increased implantation rate and clinical pregnancy rate in the third and more than three ET groups. However, there were no significant increases in the above parameters in the first and second ET groups. Our study showed that patients those who underwent the third or more than three ET cycles were inclined to higher uterine contractions and serum oxytocin level, thus atosiban treatment starting from the third ET cycle may be effective in improving embryo implantation. This is the first study to evaluate the optimal atosiban treatment window corresponding to the number of ET cycles of the patients.
这项前瞻性队列研究旨在探讨在冻融胚胎移植前给予阿托西班对不同胚胎移植（ET）周期数女性的影响。阿托西班治疗显著提高了第三次及三次以上ET组的着床率和临床妊娠率。然而，在第一次和第二次ET组中，上述参数没有显著增加。我们的研究表明，经历第三次或三次以上ET周期的患者子宫收缩和血清催产素水平较高，因此从第三次ET周期开始使用阿托西班治疗可能有效改善胚胎着床。这是第一项评估与患者ET周期数相对应的阿托西班最佳治疗窗口的研究。
