Department of Obstetrics & Gynecology, Koru Hospital, Ankara, Turkey
Department of Obstetrics & Gynecology, Faculty of Medicine, Gazi University, Ankara, Turkey
Turk J Med Sci. 2021 Jun 28;51(3):1365-1372. doi: 10.3906/sag-2012-149.
BACKGROUND/AIM: To investigate the optimal protocol for frozen-thawed embryo transfer (FET) cycles in patients who previously had a cycle cancellation due to uterine peristalsis (UP).
Thirty-four patients with previous embryo transfer (ET) cancellation due to UP during artificial cycle (AC) were included retrospectively. In the proceeding cycle, endometrium was prepared with AC (n: 23) in AC-FET group or with stimulated cycle that contains letrozole (L) (n: 11) in L-FET group. Intravenous bolus dose of 6.75 mg atosiban (Tractocile; Ferring Pharmaceuticals, Switzerland) injection was performed to all patients of AC-FET group due to UP ≥ 4/min on the planned ET day of proceeding cycle. Atosiban was not used in L-FET group. Primary outcome was live birth rate (LBR) per ET. Secondary outcomes were clinical pregnancy rate (CPR) per ET, implantation rate (IR), cycle cancellation rate.
The baseline characteristics such as age, body mass index, antral follicle count, duration of infertility, and the number of prior in vitro fertilization attempts of each group were similar. The IR, CPR per ET, LBR per ET, CPR per cycle and LBR per cycle were significantly higher; cycle cancellation rates were significantly lower in L-FET group as compared to the AC-FET group.
Endometrial preparation with letrozole significantly improves CPR and LBR in FET cycles of patients with previous cycle cancellations due to UP.
背景/目的：探讨因子宫蠕动（UP）而取消胚胎移植（ET）周期的患者进行冻融胚胎移植（FET）的最佳方案。
回顾性纳入 34 例因人工周期（AC）中 UP 而导致先前 ET 取消的胚胎移植患者。在后续周期中，AC-FET 组采用 AC（n=23）准备子宫内膜，或 L-FET 组采用含有来曲唑（L）的刺激周期（n=11）准备子宫内膜。由于在计划 ET 日 UP≥4/min，所有 AC-FET 组患者均给予静脉推注 6.75mg阿托西班（特力西尔；Ferring Pharmaceuticals，瑞士）。L-FET 组未使用阿托西班。主要结局为每 ET 的活产率（LBR）。次要结局为每 ET 的临床妊娠率（CPR）、种植率（IR）、周期取消率。
两组的基线特征如年龄、体重指数、窦卵泡计数、不孕持续时间和先前体外受精尝试次数相似。与 AC-FET 组相比，L-FET 组的 IR、每 ET 的 CPR、每 ET 的 LBR、每周期的 CPR 和每周期的 LBR 均显著升高；周期取消率显著降低。
与 AC 相比，用来曲唑准备子宫内膜可显著提高因 UP 而取消周期的患者 FET 周期的 CPR 和 LBR。
