猫α-L-艾杜糖苷酶基因定位于D4染色体。

Assignment of the feline alpha-L-iduronidase gene to chromosome D4.

作者信息

Schuchman E H, O'Brien S J, Desnick R J

机构信息

Division of Medical and Molecular Genetics, Mount Sinai School of Medicine, New York, New York 10029.

出版信息

Genomics. 1989 Apr;4(3):442-4. doi: 10.1016/0888-7543(89)90354-6.

DOI:10.1016/0888-7543(89)90354-6

PMID:2714802

Abstract

The structural gene encoding feline alpha-L-iduronidase has been assigned to chromosome D4 by electrophoretic analysis of feline-hamster somatic cell hybrids. Previously, the human alpha-L-iduronidase gene had been assigned to the chromosomal region 22pter-q11. alpha-L-Iduronidase is the first human gene on chromosome 22 to be comparatively mapped in cats and the localization of the feline gene should facilitate further genetic analysis of the feline MPS I animal model.

摘要

通过对猫 - 仓鼠体细胞杂种的电泳分析，编码猫α-L-艾杜糖苷酶的结构基因已被定位于D4染色体。此前，人类α-L-艾杜糖苷酶基因已被定位于染色体区域22pter - q11。α-L-艾杜糖苷酶是22号染色体上第一个在猫中进行比较定位的人类基因，猫基因的定位应有助于对猫黏多糖贮积症I型动物模型进行进一步的遗传分析。