Hilbrands Robert, Chen Ye, Kendal Adrian R, Adams Elizabeth, Cobbold Stephen P, Waldmann Herman, Howie Duncan
Therapeutic Immunology Group, Sir William Dunn School of Pathology, University of Oxford , Oxford , UK.
Front Immunol. 2016 Apr 11;7:124. doi: 10.3389/fimmu.2016.00124. eCollection 2016.
Regulatory T cells expressing the transcription factor Foxp3 require acquisition of a specific hypomethylation pattern to ensure optimal functional commitment, limited lineage plasticity, and long-term maintenance of tolerance. A better understanding of the molecular mechanisms involved in the generation of these epigenetic changes in vivo will contribute to the clinical exploitation of Foxp3(+) Treg. Here, we show that both in vitro and in vivo generated antigen-specific Foxp3(+) Treg can acquire Treg-specific epigenetic characteristics and prevent skin graft rejection in an animal model.
表达转录因子Foxp3的调节性T细胞需要获得特定的低甲基化模式，以确保最佳的功能定向、有限的谱系可塑性以及耐受性的长期维持。更好地理解体内这些表观遗传变化产生所涉及的分子机制，将有助于Foxp3(+)调节性T细胞的临床应用。在此，我们表明，体外和体内产生的抗原特异性Foxp3(+)调节性T细胞均可获得调节性T细胞特异性表观遗传特征，并在动物模型中预防皮肤移植排斥反应。
