van Bohemen C G, Langenberg M L, Rauws E A, Oudbier J, Weterings E, Zanen H C
Department of Medical Microbiology, University of Amsterdam, The Netherlands.
Immunol Lett. 1989 Jan 15;20(1):59-61. doi: 10.1016/0165-2478(89)90069-2.
The anaerobic bacterium Campylobacter pylori (Cp) is thought to be associated with chronic gastritis. This paper presents clinical data underpinning this view. Five patients with histological chronic gastritis as determined by diagnostic endoscopy, which was associated with Cp as determined by positive biopsy cultures, all possessed statistically raised serum IgG ELISA titers to Cp during a longitudinal period of observation of 15 months. Treatment with the antibiotics amoxycillin (clamoxyl) or colloidal bismuth subcitrate (denol) eliminated Cp within one month. Associated with this, serum IgG ELISA titers were found to decrease sharply and rapidly. Tagamet and spiramycin had little effect. Although the data are preliminary, they support the assumed Cp involvement in chronic gastritis and suggest that specific serum IgG ELISA titers to Cp are useful parameters in monitoring disease status, exceeding bacteriological culture of biopsy specimens in speed and convenience.
厌氧细菌幽门弯曲菌（Cp）被认为与慢性胃炎有关。本文提供了支持这一观点的临床数据。通过诊断性内窥镜检查确定为组织学慢性胃炎的5名患者，经活检培养呈阳性确定与Cp有关，在15个月的纵向观察期间，所有患者的血清IgG ELISA针对Cp的滴度在统计学上均升高。用抗生素阿莫西林（克拉莫西林）或枸橼酸铋钾（得乐）治疗可在1个月内清除Cp。与此同时，发现血清IgG ELISA滴度急剧迅速下降。泰胃美（西咪替丁）和螺旋霉素作用甚微。尽管数据是初步的，但它们支持了假定的Cp参与慢性胃炎的观点，并表明针对Cp的特定血清IgG ELISA滴度是监测疾病状态的有用参数，在速度和便利性方面超过了活检标本的细菌培养。
