Escós Alejandra, Risco Ana, Alsina-Beauchamp Dayanira, Cuenda Ana
Department of Immunology and Oncology, Centro Nacional de Biotecnología, Spanish National Research Council (CSIC) Madrid, Spain.
Front Cell Dev Biol. 2016 Apr 14;4:31. doi: 10.3389/fcell.2016.00031. eCollection 2016.
The protein kinases p38γ and p38δ belong to the p38 mitogen-activated protein kinase (MAPK) family. p38MAPK signaling controls many cellular processes and is one of the most conserved mechanisms in eukaryotes for the cellular response to environmental stress and inflammation. Although p38γ and p38δ are widely expressed, it is likely that they perform specific functions in different tissues. Their involvement in human pathologies such as inflammation-related diseases or cancer is starting to be uncovered. In this article we give a general overview and highlight recent advances made in defining the functions of p38γ and p38δ, focusing in innate immunity and inflammation. We consider the potential of the pharmacological targeting of MAPK pathways to treat autoimmune and inflammatory diseases and cancer.
蛋白激酶p38γ和p38δ属于p38丝裂原活化蛋白激酶（MAPK）家族。p38MAPK信号传导控制许多细胞过程，并且是真核生物中细胞对环境应激和炎症反应最保守的机制之一。尽管p38γ和p38δ广泛表达，但它们可能在不同组织中发挥特定功能。它们在人类病理学如炎症相关疾病或癌症中的作用正开始被揭示。在本文中，我们给出一个总体概述，并重点介绍在确定p38γ和p38δ功能方面取得的最新进展，重点关注先天免疫和炎症。我们考虑了MAPK途径药物靶向治疗自身免疫性疾病、炎症性疾病和癌症的潜力。
Zotero 插件