白细胞介素-12基因多态性rs3212227在中国汉族女性子痫前期中的作用
The Role of the IL-12 polymorphism rs3212227 in preeclampsia in Chinese Han Women.
作者信息
Wang Xibing, Guo Mingzhen, Li Sai, Gong Jianfeng, Song Weiqing, Wang Haiyan, Liu Shiguo
机构信息
a Obstetrical Department , Maternal and Child Health Care of Zaozhuang , Zaozhuang , China.
b Department of Blood Transfusion , The Affiliated Hospital of Qingdao University , Qingdao , China.
出版信息
Clin Exp Hypertens. 2016;38(4):388-92. doi: 10.3109/10641963.2015.1131289. Epub 2016 May 5.
OBJECTIVE
To investigate whether IL-12B rs3212227 was associated with susceptibility to PE (preeclampsia) in Chinese Han women.
METHODS
We enrolled 1000 PE patients and 1287 controls and performed rs3212227 genotyping by PCR-restriction fragment length polymorphism.
RESULTS
No significant differences in genetic distributions of IL-12B rs3212227 were observed between cases and controls (χ(2) = 4.62, p = 0.10 by genotype; χ(2) = 0.03, p = 0.87 by allele). There were also no significant differences in genotypic and allelic frequencies between mild/severe or early/late-onset PE and control subgroups.
CONCLUSION
Our data suggested that IL-12B rs3212227 might not be a critical risk factor for PE in Chinese Han women.
目的
探讨白细胞介素12B基因（IL-12B）rs3212227位点与中国汉族女性子痫前期（PE）易感性的关系。
方法
纳入1000例PE患者和1287例对照，采用聚合酶链反应-限制性片段长度多态性方法对rs3212227位点进行基因分型。
结果
病例组和对照组之间IL-12B rs3212227位点的基因分布无显著差异（基因型：χ(2)=4.62，p=0.10；等位基因：χ(2)=0.03，p=0.87）。轻度/重度或早发型/晚发型PE组与对照组亚组之间的基因型和等位基因频率也无显著差异。
结论
我们的数据表明，IL-12B rs3212227位点可能不是中国汉族女性发生PE的关键危险因素。
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