Mohácsi G, Julesz J, Berger Z, Ormos J
First Department of Medicine, University Medical School, Szeged, Hungary.
Int Urol Nephrol. 1989;21(1):31-8. doi: 10.1007/BF02549899.
We report a case of an 8-year-old girl with adrenogenital syndrome secondary to adrenocortical hyperplasia. Thirteen years later systemic lupus erythematosus developed with lupus nephritis. In spite of complex continuous immunosuppressive therapy, she died from terminal renal failure. At autopsy, extensive bilateral renal malacoplakia was discovered. The role of recurrent urinary tract infections and of immunological disturbances in the pathogenesis of malacoplakia is discussed.
我们报告一例8岁女孩，患有继发于肾上腺皮质增生的肾上腺性征异常综合征。13年后，她患上了伴有狼疮性肾炎的系统性红斑狼疮。尽管接受了复杂的持续免疫抑制治疗，她最终还是死于肾衰竭。尸检时，发现双侧肾脏广泛存在软斑病。本文讨论了复发性尿路感染和免疫紊乱在软斑病发病机制中的作用。
