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系统性硬化症患者的膀胱软斑症:一例报告及文献复习

Bladder Malakoplakia in Systemic Sclerosis Patient: A Case Report and Review Literature.

作者信息

Sirithanaphol Wichien, Sangkhamanon Sakkarn, Netwijitpan Sittichai, Foocharoen Chingching

机构信息

Division of Urology, Department of Surgery, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Pathology Department, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

出版信息

J Endourol Case Rep. 2018 Jun 1;4(1):91-93. doi: 10.1089/cren.2018.0038. eCollection 2018.

DOI:10.1089/cren.2018.0038
PMID:29967807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6025697/
Abstract

Malakoplakia, an anecdotal reactive granulomatous lesion, is a rare pathologic entity but relatively more common in genitourinary tracts. Here we report a case of malakoplakia in the urinary bladder in systemic sclerosis. The patient was a 66-year-old female treated with long-term corticosteroid and cyclophosphamide. She presented with gross hematuria, and cystoscopy and biopsy revealed malakoplakia. There was no tumor and the stains for infectious organism were all negative. To the best of our knowledge, this is the first case report of malakoplakia in a systemic sclerosis patient.

摘要

软斑病是一种罕见的病理实体,是一种偶见的反应性肉芽肿性病变,但在泌尿生殖道相对更为常见。在此,我们报告一例系统性硬化症患者膀胱软斑病的病例。该患者为66岁女性,长期接受皮质类固醇和环磷酰胺治疗。她出现肉眼血尿,膀胱镜检查和活检显示为软斑病。未发现肿瘤,感染性生物体染色均为阴性。据我们所知,这是系统性硬化症患者软斑病的首例病例报告。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d034/6025697/8393d03ada75/fig-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d034/6025697/8393d03ada75/fig-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d034/6025697/8393d03ada75/fig-1.jpg

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本文引用的文献

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Malakoplakia after kidney transplantation: Case report and literature review.肾移植后发生的软斑病:病例报告及文献综述。
Transpl Infect Dis. 2017 Oct;19(5). doi: 10.1111/tid.12731. Epub 2017 Jul 12.
2
Malakoplakia of the Urinary Bladder in a Patient with Chronic Lymphocytic Leukemia Under Ibrutinib Therapy: A Case Report.接受依鲁替尼治疗的慢性淋巴细胞白血病患者发生膀胱软斑病:一例报告
Anticancer Res. 2016 Sep;36(9):4759-62. doi: 10.21873/anticanres.11032.
3
Bilateral renal malacoplakia in systemic lupus erythematosus and adrenogenital syndrome.
系统性红斑狼疮和肾上腺生殖综合征中的双侧肾软斑病
Int Urol Nephrol. 1989;21(1):31-8. doi: 10.1007/BF02549899.
4
Malakoplakia: evidence for monocyte lysosomal abnormality correctable by cholinergic agonist in vitro and in vivo.软斑病:单核细胞溶酶体异常在体内外可被胆碱能激动剂纠正的证据
N Engl J Med. 1977 Dec 29;297(26):1413-9. doi: 10.1056/NEJM197712292972601.