Nattero G, Allais G, De Lorenzo C, Benedetto C, Zonca M, Melzi E, Massobrio M
Headache. 1989 Apr;29(4):233-8. doi: 10.1111/j.1526-4610.1989.hed22904233.x.
Eighteen patients suffering from true menstrual migraine and 12 control subjects were studied. We evaluated in different phases of the menstrual cycle and during the migraine crisis the peripheral plasma concentrations of 6-keto-PGF1 alpha (the stable metabolite of PGI2), thromboxane B2 (the stable metabolite of thromboxane A2), PGF2 alpha and PGE2. The mean values of 6-keto-PGF1 alpha in menstrual migraine sufferers are lower than in normal women throughout the whole cycle. The difference between the trends observed in the two groups is statistically significant (p less than 0.05). The plasma levels of TXB2 and of PGF2 alpha are similar in the two groups investigated, both in basal conditions and during the attack. The plasma concentrations of PGE2 are slightly lower in migraineurs in basal conditions than in normals. However, during the crisis they increase significantly (p less than 0.05). In conclusion, among all the parameters considered, PGE2 seems to play the most important role during the pain phase of the attack. The results of the present study suggest that a deficit of PGI2, one of the most important protecting agents against ischemia, might be a typical feature of menstrual migraine and might cause in these patients a vascular hypersensitivity to different ischemic stimuli.
对18例真性月经性偏头痛患者和12名对照受试者进行了研究。我们在月经周期的不同阶段以及偏头痛发作期间，评估了6-酮-前列腺素F1α（前列环素I2的稳定代谢产物）、血栓素B2（血栓素A2的稳定代谢产物）、前列腺素F2α和前列腺素E2的外周血浆浓度。月经性偏头痛患者在整个周期中6-酮-前列腺素F1α的平均值低于正常女性。两组观察到的趋势差异具有统计学意义（p<0.05）。在基础状态和发作期间，所研究的两组中血栓素B2和前列腺素F2α的血浆水平相似。在基础状态下，偏头痛患者前列腺素E2的血浆浓度略低于正常人。然而，在发作期间它们显著升高（p<0.05）。总之，在所有考虑的参数中，前列腺素E2似乎在发作的疼痛阶段起最重要的作用。本研究结果表明，作为最重要的抗缺血保护因子之一的前列环素I2缺乏，可能是月经性偏头痛的一个典型特征，并可能导致这些患者对不同缺血刺激产生血管超敏反应。
