Clinical Study on the Effects of Modified Hupo San on Reproductive Hormone Levels and Microcirculation in Patients with Menstrual Disorders of Cold Congelation and Blood Stasis Pattern.

OBJECTIVE

To investigate the effects of Modified Hupo San on reproductive hormone levels and microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern.

METHODS

A total of 102 patients from the gynecological outpatient department of our hospital were randomly assigned into a control group (n=51) and a study group (n=51). Randomization was performed using a computer-generated random number table The study group was treated with Modified Hupo San for 3 cycles, while the control group received routine therapy. Blood samples were collected on the 2nd day of menstruation before treatment and again on the 2nd day of the 4th cycle. Serum levels of TXB2, 6-keto-PGF1α, t-PA, PAI-1, estradiol (E2), and progesterone (P) were measured. Safety monitoring was performed throughout the study. Statistical analysis was conducted using SPSS 22.0, with t-tests and chi-square tests applied, and P<0.05 considered statistically significant.

RESULTS

The total effective rate of Modified Hupo San in treating menstrual disorders of cold congelation and blood stasis pattern was 96.30%. Compared with baseline, serum TXB2 and PAI-1 levels significantly decreased, while 6-keto-PGF1α, t-PA, and t-PA/PAI-1 ratio significantly increased after treatment in the study group. E2 levels significantly increased after treatment, and were higher than those in the control group (P<0.05). Progesterone showed no significant difference.

CONCLUSION

Modified Hupo San demonstrated significant therapeutic effects in improving reproductive hormones and regulating microcirculation in patients with menstrual disorders of cold congelation and blood stasis pattern, with good safety.