用于研究宿主-微生物相互作用的无菌小鼠模型
Germ-Free Mice Model for Studying Host-Microbial Interactions.
作者信息
Bhattarai Yogesh, Kashyap Purna C
机构信息
Department of Gastroenterology and Hepatology, Mayo Clinic, 200 First St. SW, Rochester, MN, 55905, USA.
出版信息
Methods Mol Biol. 2016;1438:123-35. doi: 10.1007/978-1-4939-3661-8_8.
Germ-free (GF) mice are a relevant model system to study host-microbial interactions in health and disease. In this chapter, we underscore the importance of using GF mice model to study host-microbial interactions in obesity, immune development and gastrointestinal physiology by reviewing current literature. Furthermore, we also provide a brief protocol on how to setup a gnotobiotic facility in order to properly maintain and assess GF status in mice colonies.
无菌（GF）小鼠是研究健康和疾病中宿主与微生物相互作用的相关模型系统。在本章中，我们通过回顾当前文献，强调了使用GF小鼠模型研究肥胖、免疫发育和胃肠生理学中宿主与微生物相互作用的重要性。此外，我们还提供了一份关于如何建立无菌动物设施以妥善维持和评估小鼠群体中GF状态的简要方案。
Zotero 插件