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噻二唑及其稠合衍生物的合成与生物学方面:综述

Synthetic and Biological Aspects of Thiadiazoles and their Condensed Derivatives: An Overview.

作者信息

Dwivedi Jaya, Kaur Navjeet, Kishore D, Kumari Simpal, Sharma Swapnil

机构信息

Department of Chemistry, Banasthali University, Banasthali (Rajasthan), India, P.O. Box: 304022, India.

出版信息

Curr Top Med Chem. 2016;16(26):2884-2920. doi: 10.2174/1568026616666160506144859.

Abstract

The three heteroatoms containing five membered heterocycles such as thiadiazoles have been extensively studied due to their important pharmacological activities. The thiadiazole nucleus is an important class of compounds for new drug development. The chemical and biological behavior and synthesis of thiadiazole derivatives have gained much importance in last few decades. This review article provides up to date information about exploration of new methods, developments, synthetic strategies, and their diverse pharmaceutical activities.

摘要

含三个杂原子的五元杂环,如噻二唑,因其重要的药理活性而受到广泛研究。噻二唑核是新药开发的一类重要化合物。在过去几十年中,噻二唑衍生物的化学和生物学行为及合成变得非常重要。这篇综述文章提供了有关新方法探索、进展、合成策略及其多样的药物活性的最新信息。

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