Jaiswal Shivangi, Verma Kanika, Srivastva Anamika, Arya Nikilesh, Dwivedi Jaya, Sharma Swapnil
Department of Chemistry, Banasthali Vidyapith, Banasthali, Rajasthan, India.
Department of Pharmacy, Banasthali Vidyapith, Banasthali, Rajasthan, India.
Curr Top Med Chem. 2025;25(5):493-532. doi: 10.2174/0115680266313354240807051401.
Bicyclic quinazolinone constitutes an important class of organic framework enveloping numerous biological properties which enthused organic and medicinal chemists to explore green synthetic strategies for the construction of quinazolinone hybrids with significantly improved pharmacodynamics and pharmacokinetic profiles. In this perspective, the present review summarizes the most recent green synthetic strategies, biological properties, structure-activity relationship, and molecular docking studies of the 4-quinazolinone-based scaffold. This review provides deeper insight into the hit-to-lead synthesis of quinazolinone derivatives in the development of clinically important therapeutic candidates.
双环喹唑啉酮是一类重要的有机骨架，具有多种生物学特性，这激发了有机化学家和药物化学家探索绿色合成策略，以构建具有显著改善的药效学和药代动力学特征的喹唑啉酮杂化物。从这个角度来看，本综述总结了基于4-喹唑啉酮骨架的最新绿色合成策略、生物学特性、构效关系和分子对接研究。本综述为临床上重要治疗候选药物开发中喹唑啉酮衍生物的从苗头化合物到先导化合物的合成提供了更深入的见解。
