Jiang Huixin, Tovar-Carrillo Karla, Kobayashi Takaomi
Department of Materials Science and Technology, Nagaoka University of Technology, Kamitomioka 1603-1, Nagaoka 940-2188, Japan.
Biomedical Science Institute, Universidad Autonoma de Cd. Juarez, Estocolmo y anillo envolvente del PRONAF, C.P 32315, Mexico.
Ultrason Sonochem. 2016 Sep;32:398-406. doi: 10.1016/j.ultsonch.2016.04.008. Epub 2016 Apr 7.
Ultrasound (US) drug release system using cellulose based hydrogel films was developed as triggered to mimosa. Here, the mimosa, a fascinating drug to cure injured skin, was employed as the loading drug in cellulose hydrogel films prepared with phase inversion method. The mimosa hydrogels were fabricated from dimethylacetamide (DMAc)/LiCl solution in the presence of mimosa, when the solution was exposed to ethanol vapor. The US triggered release of the mimosa from the hydrogel matrix was carried out under following conditions of US powers (0-30W) and frequencies (23, 43 and 96kHz) for different mimosa hydrogel matrix from 0.5wt% to 2wt% cellulose solution. To release the drug by US trigger from the matrix, the better medicine release was observed in the matrix prepared from the 0.5wt% cellulose solution when the 43kHz US was exposed to the aqueous solution with the hydrogel matrix. The release efficiency increased with the increase of the US power from 5 to 30W at 43kHz. Viscoelasticity of the hydrogel matrix showed that the hydrogel became somewhat rigid after the US exposure. FT-IR analysis of the mimosa hydrogel matrixes showed that during the US exposure, hydrogen bonds in the structure of mimosa-water and mimosa-cellulose were broken. This suggested that the enhancement of the mimosa release was caused by the US exposure.
开发了一种基于纤维素水凝胶薄膜的超声（US）药物释放系统，该系统受含羞草启发。在此，将一种用于治疗受损皮肤的迷人药物含羞草用作通过相转化法制备的纤维素水凝胶薄膜中的负载药物。当溶液暴露于乙醇蒸汽中时，在含羞草存在的情况下，由二甲基乙酰胺（DMAc）/氯化锂溶液制备含羞草水凝胶。在0-30W的超声功率和23、43和96kHz的频率条件下，对由0.5wt%至2wt%纤维素溶液制成的不同含羞草水凝胶基质进行超声触发含羞草从水凝胶基质中的释放。为了通过超声触发从基质中释放药物，当43kHz超声作用于含有水凝胶基质的水溶液时，在由0.5wt%纤维素溶液制备的基质中观察到了更好的药物释放。在43kHz时，释放效率随超声功率从5W增加到30W而提高。水凝胶基质的粘弹性表明，超声作用后水凝胶变得有些刚性。对含羞草水凝胶基质的傅里叶变换红外光谱（FT-IR）分析表明，在超声作用期间，含羞草-水和含羞草-纤维素结构中的氢键被破坏。这表明超声作用导致了含羞草释放的增强。
