Wang Mozhen
CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei 230026, China.
Polymers (Basel). 2016 Oct 20;8(10):373. doi: 10.3390/polym8100373.
Near-infrared (NIR)-light-triggered therapy platforms are now considered as a new and exciting possibility for clinical nanomedicine applications. As a promising photothermal agent, polypyrrole (PPy) nanoparticles have been extensively studied for the hyperthermia in cancer therapy due to their strong NIR light photothermal effect and excellent biocompatibility. However, the photothermal application of PPy based nanomaterials is still in its preliminary stage. Developing PPy based multifunctional nanomaterials for cancer treatment in vivo should be the future trend and object for cancer therapy. In this review, the synthesis of PPy nanoparticles and their NIR photothermal conversion performance were first discussed, followed by a summary of the recent progress in the design and implementation on the mulitifunctionalization of PPy or PPy based therapeutic platforms, as well as the introduction of their exciting biomedical applications based on the synergy between the photothermal conversion effect and other stimulative responsibilities.
近红外（NIR）光触发治疗平台如今被视为临床纳米医学应用中一种全新且令人兴奋的可能性。作为一种有前景的光热剂，聚吡咯（PPy）纳米颗粒因其强大的近红外光光热效应和出色的生物相容性，已在癌症治疗的热疗方面得到广泛研究。然而，基于PPy的纳米材料的光热应用仍处于初步阶段。开发用于体内癌症治疗的基于PPy的多功能纳米材料应是癌症治疗的未来趋势和目标。在这篇综述中，首先讨论了PPy纳米颗粒的合成及其近红外光热转换性能，接着总结了在PPy或基于PPy的治疗平台多功能化设计与实现方面的最新进展，以及基于光热转换效应与其他刺激作用之间的协同作用所介绍的其令人振奋的生物医学应用。
