Brown R T, Sexson S B
Department of Pediatrics and Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30322.
J Adolesc Health Care. 1989 May;10(3):179-83. doi: 10.1016/0197-0070(89)90229-5.
The short-term dose effects of methylphenidate were examined on cardiovascular measures in 11 black male adolescents diagnosed as having attention deficit hyperactivity disorder (ADHD). In a double-blind, cross-over design with randomized order, the subjects received placebo and each of three methylphenidate doses (0.15, 0.3, and 0.5 mg/kg) for a period of 2 weeks per medication dosage. Significant main effects were found for diastolic and systolic blood pressure; however, pairwise comparisons revealed a significant linear increase in diastolic blood pressure only. Because of the unexpected increase in diastolic blood pressure, careful monitoring of black adolescents who are receiving methylphenidate is recommended.
研究了哌甲酯对11名被诊断患有注意力缺陷多动障碍（ADHD）的黑人男性青少年心血管指标的短期剂量效应。采用双盲、随机顺序交叉设计，受试者接受安慰剂以及三种哌甲酯剂量（0.15、0.3和0.5毫克/千克）中的每一种，每种药物剂量服用2周。发现舒张压和收缩压有显著的主效应；然而，两两比较仅显示舒张压有显著的线性升高。由于舒张压意外升高，建议对正在服用哌甲酯的黑人青少年进行仔细监测。
