Li Shuai-Quan, Guo Rong, Gan Si-Lin, Jiang Zhong-Xing, Yue Bao-Hong, Ma Jie, Liu Yan-Fang, Xie Xin-Sheng, Sun Hui
Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China. E-mail:
Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016 Apr;24(2):311-5. doi: 10.7534/j.issn.1009-2137.2016.02.001.
To explore the expression of CC-chemokine Receptor 7 (CCR7) in adult acute leukemia patients, and to analyze the relationship of CCR7 expression with the clinical characteristics of patients.
The expression of CCR7 in bone marrow samples from adult acute leukemia patients were detected by flow cytometry (FCM), the relationship of CCR7 expression with the clinical characteristics of patients such as sex, age, WBC count, blast cell ratio, CD56 expression, molecular biology, cell genetics, risk stratification, extramedullary infiltration was analyzed.
The expression rate of CCR7 in adult ALL and AML patients was 36.8% and 9.6%, respectively, and the expression level of CCR7 in ALL patients was higher than that in AML patients (P < 0.05). The extramedullary infiltration rate was 100% and 41.7 % for CCR7 positive and negative groups of ALL, respectively (P < 0.05). While the mean fluorescence intensity (MFI) in extramedullary infiltration group of ALL was higher than that in none-extramedullary infiltration group of ALL (50.00 ± 10.42 vs 18.14 ± 1.39), respectively (P < 0.05).
CCR7 is higher expressed in adult acute leukemia cells, moreover its expression rate in ALL is higher than that in AML, and the expression of CCR7 is related with extramedullary infiltration in ALL.
探讨CC趋化因子受体7（CCR7）在成人急性白血病患者中的表达情况，并分析CCR7表达与患者临床特征的关系。
采用流式细胞术（FCM）检测成人急性白血病患者骨髓样本中CCR7的表达，分析CCR7表达与患者性别、年龄、白细胞计数、原始细胞比例、CD56表达、分子生物学、细胞遗传学、危险分层、髓外浸润等临床特征的关系。
成人急性淋巴细胞白血病（ALL）和急性髓系白血病（AML）患者中CCR7的表达率分别为36.8%和9.6%，ALL患者中CCR7的表达水平高于AML患者（P<0.05）。ALL患者CCR7阳性组和阴性组的髓外浸润率分别为100%和41.7%（P<0.05）。ALL患者髓外浸润组的平均荧光强度（MFI）高于非髓外浸润组（分别为50.00±10.42和18.14±1.39）（P<0.05）。
CCR7在成人急性白血病细胞中高表达，且其在ALL中的表达率高于AML，CCR7的表达与ALL患者的髓外浸润有关。
