甲状旁腺激素信号传导与骨重塑的表观遗传调控
PTH Signaling and Epigenetic Control of Bone Remodeling.
作者信息
Ricarte Florante, Nakatani Teruyo, Partridge Nicola
机构信息
New York University School of Medicine, Sackler Institute of Graduate Biomedical Sciences, Department of Biochemistry and Molecular Pharmacology, New York, NY 10016.
New York University College of Dentistry, Department of Basic Science and Craniofacial Biology, New York, NY 10010.
出版信息
Curr Mol Biol Rep. 2016 Mar;2(1):55-61. doi: 10.1007/s40610-016-0033-7. Epub 2016 Feb 3.
Abstract
As our understanding of the mechanisms that govern bone development advance, the role of epigenetic modifications in these processes become increasingly evident. Interestingly, in parathyroid hormone (PTH)-induced bone metabolism and remodeling, recent evidence shows that PTH signaling employs a particular facet of the epigenetic machinery to elicit its desired effects. In this review, we briefly discuss the known epigenetic events occurring in cells of the osteoblast lineage. More specifically, we elaborate on current findings that reveal the utilization of histone deacetylating enzymes (HDACs) in PTH-regulated modulation of gene expression in bone.
摘要
随着我们对骨骼发育调控机制的理解不断深入，表观遗传修饰在这些过程中的作用日益明显。有趣的是，在甲状旁腺激素（PTH）诱导的骨代谢和重塑过程中，最近的证据表明，PTH信号传导利用表观遗传机制的一个特定方面来产生其预期效果。在这篇综述中，我们简要讨论了成骨细胞谱系细胞中已知的表观遗传事件。更具体地说，我们详细阐述了目前的研究结果，这些结果揭示了组蛋白去乙酰化酶（HDACs）在PTH调节的骨基因表达调控中的作用。
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