Barth J H, Cherry C A, Wojnarowska F, Dawber R P
Department of Dermatology, Slade Hospital, Headington, Oxford, United Kingdom.
J Clin Endocrinol Metab. 1989 May;68(5):966-70. doi: 10.1210/jcem-68-5-966.
We treated 22 hirsute women with spironolactone in an open trial to determine whether it caused objective changes in hair growth. Among them, 18 women completed 12 months therapy with 200 mg spironolactone daily. During this period, the mean daily linear growth rates of hair on the face, abdomen, and thigh were reduced to 66% (P less than 0.001), 75% (P less than 0.01), and 72% (P less than 0.001) of their pretreatment values. The mean hair shaft diameters were reduced to 83% (P less than 0.01) on the face, 88% (P less than 0.001) on the arm, 74% (P less than 0.01) on the abdomen, and 80% (P less than 0.001) on the thigh. Daily hair volume production was calculated from the diameter and daily growth rate; it was reduced to 60% (P less than 0.01) on the face, 52% (P less than 0.01) on the arm, 34% (P less than 0.001) on the abdomen, and 48% (P less than 0.001) on the thigh. Six of the 18 women who completed the study developed midcycle vaginal bleeding, and 3 women had previously irregular menstrual cycles regulated. We conclude that spironolactone is effective and well tolerated for hirsute women.
我们在一项开放性试验中用螺内酯治疗了22名多毛女性，以确定其是否会引起毛发生长的客观变化。其中，18名女性完成了为期12个月、每日服用200毫克螺内酯的治疗。在此期间，面部、腹部和大腿毛发的平均每日线性生长速率降至治疗前值的66%（P<0.001）、75%（P<0.01）和72%（P<0.001）。毛发直径均值在面部降至83%（P<0.01），在手臂降至88%（P<0.001），在腹部降至74%（P<0.01），在大腿降至80%（P<0.001）。每日毛发量由直径和每日生长速率计算得出；在面部降至60%（P<0.01），在手臂降至52%（P<0.01），在腹部降至34%（P<0.001），在大腿降至48%（P<0.001）。完成研究的18名女性中有6名出现了月经周期中期阴道出血，3名既往月经周期不规律的女性月经周期恢复正常。我们得出结论，螺内酯对多毛女性有效且耐受性良好。
