SIRT2 orchestrates the DNA damage response.
作者信息
Zhang Hui, Head PamelaSara E, Yu David S
机构信息
a Department of Radiation Oncology , Emory University School of Medicine , Atlanta , GA , USA.
出版信息
Cell Cycle. 2016 Aug 17;15(16):2089-2090. doi: 10.1080/15384101.2016.1184517. Epub 2016 May 6.
Abstract
摘要
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本文引用的文献
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ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA.SIRT2介导的ATR去乙酰化通过促进与RPA-ssDNA的结合驱动ATR检查点激活。
Cell Rep. 2016 Feb 16;14(6):1435-1447. doi: 10.1016/j.celrep.2016.01.018. Epub 2016 Feb 4.
2
SIRT2 directs the replication stress response through CDK9 deacetylation.SIRT2 通过 CDK9 的去乙酰化作用来指导复制应激反应。
Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13546-51. doi: 10.1073/pnas.1301463110. Epub 2013 Jul 29.
3
SIRT2 maintains genome integrity and suppresses tumorigenesis through regulating APC/C activity.SIRT2 通过调节 APC/C 的活性来维持基因组的完整性并抑制肿瘤发生。
Cancer Cell. 2011 Oct 18;20(4):487-99. doi: 10.1016/j.ccr.2011.09.004.
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CBP/p300-mediated acetylation of histone H3 on lysine 56.CBP/p300介导的组蛋白H3赖氨酸56位点的乙酰化
Nature. 2009 May 7;459(7243):113-7. doi: 10.1038/nature07861. Epub 2009 Mar 8.
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Acetylation of Sirt2 by p300 attenuates its deacetylase activity.p300介导的Sirt2乙酰化作用减弱了其去乙酰化酶活性。
Biochem Biophys Res Commun. 2008 Oct 31;375(4):576-80. doi: 10.1016/j.bbrc.2008.08.042. Epub 2008 Aug 21.
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