Burgess E, Duff H, Wilkes P
Department of Medicine, University of Calgary, Alberta, Canada.
J Clin Pharmacol. 1989 Feb;29(2):112-3. doi: 10.1002/j.1552-4604.1989.tb03296.x.
The pharmacokinetics of a single intravenous dose of propafenone were studied in subjects with normal renal function (n = 5), renal insufficiency (n = 5), and renal failure (n = 3). No difference in central volume of distribution, total ischemic clearance or terminal half-life existed. None of the pharmacokinetic parameters examined correlated to creatinine clearance. Within the confines of the small number of patients studied, there does not appear to be any effect of renal insufficiency or failure on single-dose propafenone disposition.
在肾功能正常（n = 5）、肾功能不全（n = 5）和肾衰竭（n = 3）的受试者中研究了单次静脉注射普罗帕酮的药代动力学。分布中心容积、总缺血清除率或终末半衰期均无差异。所检测的药代动力学参数均与肌酐清除率无关。在所研究的少数患者范围内，肾功能不全或肾衰竭似乎对单次剂量普罗帕酮的处置没有任何影响。
