Burgess E D, Duff H J
Department of Medicine, University of Calgary, Alberta, Canada.
Pharmacotherapy. 1989;9(5):331-3. doi: 10.1002/j.1875-9114.1989.tb04145.x.
Propafenone kinetics were studied after intravenous and oral dosing in a patient with end-stage renal disease. Hemodialysis was performed within 10 hours of dosing in order to assess its effects. After intravenous administration of 70 mg propafenone, total-body clearance was 10.5 ml/min/kg before and 10.4 ml/min/kg during hemodialysis. After a single oral dose of 300 mg, clearance was 19.4 ml/min/kg before and 18.9 ml/min/kg during hemodialysis. Bioavailability was 48%.
在一名终末期肾病患者中，研究了静脉注射和口服普罗帕酮后的动力学情况。给药后10小时内进行血液透析，以评估其效果。静脉注射70毫克普罗帕酮后，血液透析前全身清除率为10.5毫升/分钟/千克，血液透析期间为10.4毫升/分钟/千克。单次口服300毫克后，血液透析前清除率为19.4毫升/分钟/千克，血液透析期间为18.9毫升/分钟/千克。生物利用度为48%。
