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Antiepileptic Drug Treatment of Epilepsy in Children.儿童癫痫的抗癫痫药物治疗
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本文引用的文献

1
Quinidine in the treatment of KCNT1-positive epilepsies.奎尼丁治疗KCNT1阳性癫痫
Ann Neurol. 2015 Dec;78(6):995-9. doi: 10.1002/ana.24520. Epub 2015 Nov 18.
2
Pharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine.Dravet综合征反义敲低斑马鱼模型的药理学特征:血清素激动剂芬氟拉明对癫痫发作的抑制作用
PLoS One. 2015 May 12;10(5):e0125898. doi: 10.1371/journal.pone.0125898. eCollection 2015.
3
Functional analysis of potassium channels in Kv7.2 G271V mutant causing early onset familial epilepsy.导致早发性家族性癫痫的Kv7.2 G271V突变体中钾通道的功能分析
Brain Res. 2015 Aug 7;1616:112-22. doi: 10.1016/j.brainres.2015.04.060. Epub 2015 May 7.
4
Perceived efficacy of cannabidiol-enriched cannabis extracts for treatment of pediatric epilepsy: A potential role for infantile spasms and Lennox-Gastaut syndrome.富含大麻二酚的大麻提取物治疗小儿癫痫的感知疗效:对婴儿痉挛症和伦诺克斯-加斯托综合征的潜在作用。
Epilepsy Behav. 2015 Jun;47:138-41. doi: 10.1016/j.yebeh.2015.04.009. Epub 2015 Apr 29.
5
Early and effective treatment of KCNQ2 encephalopathy.KCNQ2 脑病的早期有效治疗。
Epilepsia. 2015 May;56(5):685-91. doi: 10.1111/epi.12984. Epub 2015 Apr 16.
6
Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy.家长对口服大麻提取物治疗难治性癫痫疗效的报告。
Epilepsy Behav. 2015 Apr;45:49-52. doi: 10.1016/j.yebeh.2015.02.043. Epub 2015 Apr 3.
7
Efficacy and safety of perampanel in adolescent patients with drug-resistant partial seizures in three double-blind, placebo-controlled, phase III randomized clinical studies and a combined extension study.在三项双盲、安慰剂对照的III期随机临床试验及一项合并的扩展研究中,吡仑帕奈治疗青少年耐药性部分性癫痫发作的疗效与安全性。
Eur J Paediatr Neurol. 2015 Jul;19(4):435-45. doi: 10.1016/j.ejpn.2015.02.008. Epub 2015 Mar 5.
8
Effectiveness and tolerability of perampanel in children and adolescents with refractory epilepsies: first experiences.吡仑帕奈治疗儿童和青少年难治性癫痫的有效性和耐受性:初步经验。
Neuropediatrics. 2015 Apr;46(2):110-6. doi: 10.1055/s-0035-1546276. Epub 2015 Mar 2.
9
Safety and tolerability of zonisamide in paediatric patients with epilepsy.唑尼沙胺在癫痫患儿中的安全性和耐受性。
Eur J Paediatr Neurol. 2014 Nov;18(6):747-58. doi: 10.1016/j.ejpn.2014.07.005. Epub 2014 Jul 29.
10
Targeted treatment of migrating partial seizures of infancy with quinidine.以奎尼丁靶向治疗婴儿部分性发作性癫痫。
Ann Neurol. 2014 Sep;76(3):457-61. doi: 10.1002/ana.24229. Epub 2014 Jul 26.

儿童癫痫综合征的靶向治疗。

Targeted Treatment in Childhood Epilepsy Syndromes.

机构信息

Great Ormond Street Hospital for Children NHS Trust, Great Ormond Street, London, WC1N 3JH, UK.

Clinical Neurosciences, 30 Guilford St, London, WC1N 1EH, UK.

出版信息

Curr Treat Options Neurol. 2016 Jun;18(6):29. doi: 10.1007/s11940-016-0407-4.

DOI:10.1007/s11940-016-0407-4
PMID:27154366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4859845/
Abstract

The mainstay of treatment of epilepsy has been antiepileptic drugs; however, despite the emergence of new agents, a consistent proportion remain drug-resistant. Newer AEDs show promise. However, as it becomes clear that the epilepsies are a group of diseases rather than a single disorder the prospect of targeted treatment in some may become a reality.

摘要

癫痫治疗的主要手段一直是抗癫痫药物;然而,尽管出现了新的药物,仍有相当一部分患者对药物耐药。新型抗癫痫药物显示出希望。然而,随着人们越来越清楚地认识到癫痫是一组疾病而不是单一的疾病,针对某些疾病的靶向治疗的前景可能成为现实。