儿童结核病患者的异烟肼头发浓度：一项概念验证研究。
Isoniazid hair concentrations in children with tuberculosis: a proof of concept study.
作者信息
Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet L Z, Ramachandran G, Dooley K E, Gupta A, Gandhi M
机构信息
Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India; Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Byramjee-Jeejeebhoy Medical College Clinical Trials Unit, Pune, India.
出版信息
Int J Tuberc Lung Dis. 2016 Jun;20(6):844-7. doi: 10.5588/ijtld.15.0882.
Abstract
Assessing treatment adherence and quantifying exposure to anti-tuberculosis drugs among children is challenging. We undertook a 'proof of concept' study to assess the drug concentrations of isoniazid (INH) in hair as a therapeutic drug monitoring tool. Children aged <12 years initiated on a thrice-weekly treatment regimen including INH (10 mg/kg) for newly diagnosed tuberculosis were enrolled. INH concentrations in hair were measured using liquid chromatography-tandem mass spectrometry at 1, 2, 4 and 6 months after initiating anti-tuberculosis treatment. We found that INH hair concentrations in all children on thrice-weekly INH were detectable and displayed variability across a dynamic range.
摘要
评估儿童的治疗依从性以及量化其抗结核药物暴露情况具有挑战性。我们开展了一项“概念验证”研究，以评估头发中异烟肼（INH）的药物浓度作为一种治疗药物监测工具。纳入了年龄小于12岁、开始接受包括INH（10mg/kg）在内的每周三次治疗方案用于新诊断结核病的儿童。在开始抗结核治疗后的1、2、4和6个月，使用液相色谱-串联质谱法测量头发中的INH浓度。我们发现，所有接受每周三次INH治疗的儿童头发中的INH浓度均可检测到，并且在动态范围内呈现出变异性。
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