Casanegra Ana I, Stoner Julie A, Tafur Alfonso J, Pereira H Anne, Rathbun Suman W, Gardner Andrew W
Vascular Medicine Program, Cardiovascular Section, Department of Medicine, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA
Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, OK, USA.
Vasc Med. 2016 Oct;21(5):437-444. doi: 10.1177/1358863X16644059. Epub 2016 May 7.
The aim of this study was to determine if galectin-3 levels were different between participants with peripheral artery disease (PAD) and controls, and to describe its relationship with markers of early atherosclerosis. Sixty participants were recruited into two groups: a PAD group (n=31), ankle-brachial index (ABI) ⩽0.90 and a normal ABI group (n=29), ABI 1.0-1.4. PAD participants were older (68.6 vs 61.8 years, p=0.037), more commonly men (68% vs 38%, p=0.02), and with more cardiovascular risk factors (p<0.001). Galectin-3 was 22% higher in PAD participants (mean±SD: 17.6±4.7 vs 14.4±4.1 ng/mL, p<0.01). The odds ratio for galectin-3 in PAD to be 1 ng/mL higher than the participants with normal ABI was 1.19, after adjusting by age and gender (p=0.014). High-sensitivity C-reactive protein (hs-CRP) and homeostatic model assessment (HOMA) were positively associated with galectin-3 in the age- and gender-adjusted model, while arterial elasticity and microalbuminuria were not. In conclusion, galectin-3 levels were higher in participants with PAD.
本研究的目的是确定外周动脉疾病（PAD）患者与对照组之间的半乳糖凝集素-3水平是否存在差异，并描述其与早期动脉粥样硬化标志物的关系。60名参与者被分为两组：PAD组（n = 31），踝臂指数（ABI）≤0.90；正常ABI组（n = 29），ABI为1.0 - 1.4。PAD参与者年龄更大（68.6岁对61.8岁，p = 0.037），男性更常见（68%对38%，p = 0.02），且有更多心血管危险因素（p < 0.001）。PAD参与者的半乳糖凝集素-3水平高22%（均值±标准差：17.6±4.7对14.4±4.1 ng/mL，p < 0.01）。在按年龄和性别调整后，PAD患者中半乳糖凝集素-3比正常ABI参与者高1 ng/mL的优势比为1.19（p = 0.014）。在年龄和性别调整模型中，高敏C反应蛋白（hs-CRP）和稳态模型评估（HOMA）与半乳糖凝集素-3呈正相关，但动脉弹性和微量白蛋白尿与半乳糖凝集素-3无相关性。总之，PAD参与者的半乳糖凝集素-3水平更高。
