在酒精性肝病中，库普弗细胞数量正常，但它们的溶菌酶含量降低。

Kupffer cell number is normal, but their lysozyme content is reduced in alcoholic liver disease.

作者信息

Kelly P M, Heryet A R, McGee J O

机构信息

University of Oxford, Nuffield Department of Pathology, John Radcliffe Hospital, Headington, U.K.

出版信息

J Hepatol. 1989 Mar;8(2):173-80. doi: 10.1016/0168-8278(89)90005-6.

DOI:10.1016/0168-8278(89)90005-6

PMID:2715620

Abstract

A quantitative immunohistochemical study of Kupffer cells in liver biopsies from alcoholics was carried out. Two markers were compared, lysozyme and an antimacrophage monoclonal antibody EMB/11. The results showed that there is no significant reduction in Kupffer cell numbers in acute and chronic alcoholic liver disease but that there is a reduction in the number of Kupffer cells staining positively for lysozyme. Thus, those clinical phenomena such as endotoxaemia in alcoholic liver disease are not due to reduction in Kupffer cell number but perhaps to a functional deficit in these cells.

摘要

对酒精性肝病患者肝活检组织中的库普弗细胞进行了定量免疫组织化学研究。比较了两种标志物，即溶菌酶和抗巨噬细胞单克隆抗体EMB/11。结果显示，在急性和慢性酒精性肝病中，库普弗细胞数量没有显著减少，但溶菌酶染色阳性的库普弗细胞数量减少。因此，酒精性肝病中的内毒素血症等临床现象并非由于库普弗细胞数量减少，而是可能由于这些细胞的功能缺陷。