Chen Yuehong, Yang Yuan, Liu Gang
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan, China.
Department of Rheumatology and Immunology, West China Hospital, Sichuan University, 37 Guoxue Xiang, Chengdu, Sichuan, China.
Arch Med Res. 2016 Feb;47(2):134-41. doi: 10.1016/j.arcmed.2016.05.001. Epub 2016 May 6.
We undertook this study to assess the association between osteoprotegerin (OPG) gene polymorphisms and rheumatoid arthritis (RA) susceptibility.
English language databases of PubMed Medline and OVID EMBASE and Chinese databases of China National Knowledge Infrastructure, Chinese Biomedical Literature Database and Wanfang were searched to identify case-control studies studied the relationship between OPG gene polymorphisms and RA susceptibility. Two reviewers separately and repeatedly screened searched studies according to study selection criteria and collected data. Data analyses of five comparison models-allelic model, heterozygote model, homozygote model, dominant model and recessive model-were conducted in Review Manager Software 5.1.
A total of five studies including 1713 RA cases and 1845 controls were eligible in this meta-analysis. Single nucleotide polymorphisms (SNPs), rs3102735 T/C or A/G, rs2073618 G/C and rs3134069 T/G, of OPG gene were studied. Data from five studies of SNPs rs3102735 were OR = 1.22, 95% CI 0.86-1.73, OR = 1.06, 95% CI 0.86-1.32, OR = 1.79, 95% CI 0.65-4.89, OR = 1.16, 95% CI 0.85-1.59, OR = 1.73, 95% CI 0.67-4.46, respectively, for the five comparison models in order. For SNPs rs2073618, results derived from three studies were OR = 1.06, 95% CI 0.95-1.19, OR = 1.11, 95% CI 0.94-1.31, OR = 1.09, 95% CI 0.84-1.42, OR = 1.10, 95% CI 0.94-1.30, OR = 1.04, 95% CI 0.84-1.30, respectively. With respect to SNPs rs3134069, only one study assessed the associations, reporting no statistically significant results among the five comparison models.
SNPs rs3102735, rs2073618 and rs3134069 of OPG gene polymorphisms are not susceptibility factors of RA based on currently available evidence.
我们开展本研究以评估骨保护素（OPG）基因多态性与类风湿关节炎（RA）易感性之间的关联。
检索英文数据库PubMed Medline和OVID EMBASE以及中文数据库中国知网、中国生物医学文献数据库和万方，以识别研究OPG基因多态性与RA易感性之间关系的病例对照研究。两名评审员根据研究选择标准分别并反复筛选检索到的研究并收集数据。在Review Manager Software 5.1中对五个比较模型——等位基因模型、杂合子模型、纯合子模型、显性模型和隐性模型——进行数据分析。
本荟萃分析共纳入五项研究，包括1713例RA病例和1845例对照。研究了OPG基因的单核苷酸多态性（SNP），即rs3102735 T/C或A/G、rs2073618 G/C和rs3134069 T/G。rs3102735的五项研究数据在五个比较模型中依次为：OR = 1.22，95% CI 0.86 - 1.73；OR = 1.06，95% CI 0.86 - 1.32；OR = 1.79，95% CI 0.65 - 4.89；OR = 1.16，95% CI 0.85 - 1.59；OR = 1.73，95% CI 0.67 - 4.46。对于rs2073618，三项研究的结果分别为：OR = 1.06，95% CI 0.95 - 1.19；OR = 1.11，95% CI 0.94 - 1.31；OR = 1.09，95% CI 0.84 - 1.42；OR = 1.10，95% CI 0.94 - 1.30；OR = 1.04，95% CI 0.84 - 1.30。关于rs3134069，只有一项研究评估了其关联性，在五个比较模型中均未报告有统计学意义的结果。
基于现有证据，OPG基因多态性的rs3102735、rs2073618和rs3134069不是RA的易感因素。
