口服西地那非治疗新生儿布洛芬使用后发生的重度肺动脉高压
Oral Sildenafil for Severe Pulmonary Hypertension Developing after Ibuprofen Use in a Neonate.
作者信息
Rodriguez-Castano M Jose, Aleo Esther, Arruza Luis
机构信息
Department of Neonatology, Hospital Clinico San Carlos, Madrid, Spain. Correspondence to: Dr M Jose Rodriguez-Castano, Department of Neonatology Hospital Clinico San Carlos, Profesor Martin Lagos s/n, 28040, Madrid, Spain.
出版信息
Indian Pediatr. 2016 Apr;53(4):349-50. doi: 10.1007/s13312-016-0852-x.
BACKGROUND
Severe pulmonary hypertension may following ibuprofen administration for ductal closure.
CASE CHARACTERISTICS
An extremely preterm infant who developed severe pulmonary hypertension unresponsive to inhaled nitric oxide after ibuprofen administration.
OUTCOME
Pulmonary hypertension reversed after the administration of oral sildenafil, but the infant died due to complications related to bronchopulmonary dysplasia.
MESSAGE
Sildenafil may have a role in treatment of severe pulmonary hypertension after ibuprofen treatment for ductal closure.
背景
布洛芬用于动脉导管闭合术后可能会引发严重肺动脉高压。
病例特征
一名极早产儿在使用布洛芬后出现严重肺动脉高压，对吸入一氧化氮治疗无反应。
结果
口服西地那非后肺动脉高压得到缓解，但该婴儿因支气管肺发育不良相关并发症死亡。
启示
在布洛芬用于动脉导管闭合术后引发的严重肺动脉高压治疗中，西地那非可能有一定作用。
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