SCF泛素连接酶复合体的最新进展：临床意义
Recent advances in SCF ubiquitin ligase complex: Clinical implications.
作者信息
Zheng Nana, Zhou Quansheng, Wang Zhiwei, Wei Wenyi
机构信息
The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, China.
The Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou 215123, China; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA.
出版信息
Biochim Biophys Acta. 2016 Aug;1866(1):12-22. doi: 10.1016/j.bbcan.2016.05.001. Epub 2016 May 5.
F-box proteins, which are subunit recruiting modules of SCF (SKP1-Cullin 1-F-box protein) E3 ligase complexes, play critical roles in the development and progression of human malignancies through governing multiple cellular processes including cell proliferation, apoptosis, invasion and metastasis. Moreover, there are emerging studies that lead to the development of F-box proteins inhibitors with promising therapeutic potential. In this article, we describe how F-box proteins including but not restricted to well-established Fbw7, Skp2 and β-TRCP, are involved in tumorigenesis. However, in-depth investigation is required to further explore the mechanism and the physiological contribution of undetermined F-box proteins in carcinogenesis. Lastly, we suggest that targeting F-box proteins could possibly open new avenues for the treatment and prevention of human cancers.
F-box蛋白是SCF（SKP1- Cul1- F-box蛋白）E3泛素连接酶复合物的亚基招募模块，通过调控包括细胞增殖、凋亡、侵袭和转移在内的多种细胞过程，在人类恶性肿瘤的发生和发展中发挥关键作用。此外，越来越多的研究促使开发出具有潜在治疗潜力的F-box蛋白抑制剂。在本文中，我们描述了包括但不限于已被充分证实的Fbw7、Skp2和β-TRCP等F-box蛋白如何参与肿瘤发生。然而，需要深入研究以进一步探索未确定的F-box蛋白在致癌作用中的机制和生理作用。最后，我们认为靶向F-box蛋白可能为人类癌症的治疗和预防开辟新途径。
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