Mach Robert H, Schwarz Sally W
Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA.
Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA.
PET Clin. 2010 Apr;5(2):131-53. doi: 10.1016/j.cpet.2010.02.002. Epub 2010 Jun 3.
The primary limitation on the development of new radiotracers for use with positron emission tomography (PET) is the time constraints created by working with radionuclides with the short half-lives inherent to carbon 11 and fluorine 18, the main radionuclides used in PET radiotracer development. In the past decade there have been several developments in the radiosynthetic methods used in PET chemistry, advances that are expected to lead to an increase in the number of radiotracers making the transition from clinical research studies to clinical PET studies. This article reviews developments in PET radiochemistry that will facilitate this process and discusses the application of these basic principles of PET radiotracer development in central nervous system research. Current status of regulatory requirements for the development of new PET radiotracers for imaging studies in humans is reviewed.
用于正电子发射断层扫描（PET）的新型放射性示踪剂开发的主要限制在于，使用碳-11和氟-18这两种PET放射性示踪剂开发中使用的主要放射性核素所固有的短半衰期放射性核素时所产生的时间限制。在过去十年中，PET化学中使用的放射性合成方法有了多项进展，预计这些进展将导致从临床研究过渡到临床PET研究的放射性示踪剂数量增加。本文回顾了有助于这一过程的PET放射化学进展，并讨论了PET放射性示踪剂开发的这些基本原理在中枢神经系统研究中的应用。还回顾了用于人体成像研究的新型PET放射性示踪剂开发的监管要求现状。
