新白蛇醇通过上调PTEN抑制人胆管癌细胞的细胞生长。
Neoalbaconol inhibits cell growth of human cholangiocarcinoma cells by up-regulating PTEN.
作者信息
Zhou Guang-Yao, Pan Chen-Wei, Jin Ling-Xiang, Zheng Jian-Jian, Yi Yong-Xiang
机构信息
Department of Infectious Disease, The Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325027, China.
Wenzhou Key Laboratory of Surgery, The First Affiliated Hospital of Wenzhou Medical University Wenzhou, Zhejiang 325000, China.
出版信息
Am J Transl Res. 2016 Feb 15;8(2):496-505. eCollection 2016.
Abstract
The recently isolated small-molecule neoalbaconol (NA) from Albatrellus confluens has been suggested to possess the ability to inhibit cell growth of many cancer cells. In this study, we investigated the role of NA in the regulation of cell apoptosis in human cholangiocarcinoma cell lines both in vitro and in vivo. Our results indicate that NA could induce cancer cell death via the AKT pathway by targeting phosphorate and tension homolog detected on chromosome 10 (PTEN) and supported the feasibility of NA being a novel chemotherapeutic treatment for human cholangiocarcinoma.
摘要
最近从融合秃牛肝菌中分离出的小分子新茯苓二醇（NA）被认为具有抑制多种癌细胞生长的能力。在本研究中，我们在体外和体内研究了NA在人胆管癌细胞系细胞凋亡调控中的作用。我们的结果表明，NA可通过靶向10号染色体上检测到的磷酸酶和张力同源物（PTEN），经由AKT途径诱导癌细胞死亡，并支持了NA作为人胆管癌新型化疗药物的可行性。
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