Miana Leonardo Augusto, Canêo Luiz Fernando, Tanamati Carla, Penha Juliano Gomes, Guimarães Vanessa Alves, Miura Nana, Galas Filomena Regina Barbosa Gomes, Jatene Marcelo Biscegli
Clinics Hospital, Medical School, University of São Paulo, São Paulo, SP, Brazil.
Rev Bras Cir Cardiovasc. 2015 Jul-Aug;30(4):409-16. doi: 10.5935/1678-9741.20150053.
Post-cardiotomy myocardial dysfunction requiring mechanical circulatory support occurs in about 0.5% of cases. In our environment, the use of extracorporeal membrane oxygenation has been increasing in recent years.
To evaluate the impact of investment in professional training and improvement of equipment in the rate of weaning from extracorporeal membrane oxygenation and survival.
A retrospective study. Fifty-six pediatric and/or congenital heart patients underwent post-cardiotomy extracorporeal membrane oxygenation at our institution between November 1999 and July 2014. We divided this period into two phases: phase I, 36 cases (before the structuring of the extracorporeal membrane oxygenation program) and phase II, 20 cases (after the extracorporeal membrane oxygenation program implementation) with investment in training and equipment). Were considered as primary outcomes: extracorporeal membrane oxygenation weaning and survival to hospital discharge. The results in both phases were compared using Chi-square test. To identify the impact of the different variables we used binary logistic regression analysis.
Groups were comparable. In phase I, 9 patients (25%) were weaned from extracorporeal membrane oxygenation, but only 2 (5.5%) were discharged. In phase II, extracorporeal membrane oxygenation was used in 20 patients, weaning was possible in 17 (85%), with 9 (45%) hospital discharges (P<0.01). When the impact of several variables on discharge and weaning of extracorporeal membrane oxygenation was analyzed, we observe that phase II was an independent predictor of better results (P<0.001) and need for left cavities drainage was associated with worse survival (P=0.045).
The investment in professional training and improvement of equipment significantly increased extracorporeal membrane oxygenation results.
心脏手术后需要机械循环支持的心肌功能障碍发生率约为0.5%。在我们所处的环境中,近年来体外膜肺氧合的使用一直在增加。
评估专业培训投资和设备改进对体外膜肺氧合撤机率和生存率的影响。
一项回顾性研究。1999年11月至2014年7月期间,56例儿科和/或先天性心脏病患者在我院接受了心脏手术后体外膜肺氧合治疗。我们将这一时期分为两个阶段:第一阶段,36例(体外膜肺氧合项目构建之前);第二阶段,20例(体外膜肺氧合项目实施之后,有培训和设备投资)。主要结局指标为:体外膜肺氧合撤机和出院生存率。使用卡方检验比较两个阶段的结果。为确定不同变量的影响,我们采用二元逻辑回归分析。
两组具有可比性。在第一阶段,9例患者(25%)成功撤离体外膜肺氧合,但只有2例(5.5%)出院。在第二阶段,20例患者使用了体外膜肺氧合,其中17例(85%)成功撤机,9例(45%)出院(P<0.01)。当分析多个变量对体外膜肺氧合撤机和出院的影响时,我们观察到第二阶段是更好结果的独立预测因素(P<0.001),而左心腔引流需求与较差的生存率相关(P=0.045)。
专业培训投资和设备改进显著提高了体外膜肺氧合治疗效果。