桑黄菌丝体中的紫罗兰酮衍生物及其对活化大鼠肝星状细胞的抑制作用。
Ionone Derivatives from the Mycelium of Phellinus linteus and the Inhibitory Effect on Activated Rat Hepatic Stellate Cells.
作者信息
Huang Shiow-Chyn, Kuo Ping-Chung, Hung Hsin-Yi, Pan Tai-Long, Chen Fu-An, Wu Tian-Shung
机构信息
Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan.
School of Pharmacy, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
出版信息
Int J Mol Sci. 2016 May 6;17(5):681. doi: 10.3390/ijms17050681.
Three new γ-ionylideneacetic acid derivatives, phellinulins A-C (1-3), were characterized from the mycelium extract of Phellinus linteus. The chemical structures were established based on the spectroscopic analysis. In addition, phellinulin A (1) was subjected to the examination of effects on activated rat hepatic stellate cells and exhibited significant inhibition of hepatic fibrosis.
从桑黄菌丝体提取物中鉴定出三种新的γ-紫罗酮亚基乙酸衍生物，桑黄菌素A-C（1-3）。基于光谱分析确定了其化学结构。此外，对桑黄菌素A（1）进行了对活化大鼠肝星状细胞影响的研究，结果显示其对肝纤维化具有显著抑制作用。
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