松杉灵芝菌丝体的保肝作用原理及其他化学成分。
Hepatoprotective Principles and Other Chemical Constituents from the Mycelium of Phellinus linteus.
机构信息
Department of Pharmacy, Chia-Nan University of Pharmacy and Science, Tainan 717, Taiwan.
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
出版信息
Molecules. 2018 Jul 12;23(7):1705. doi: 10.3390/molecules23071705.
In the dimethylnitrosamine (DMN)-induced hepatic fibrosis Wistar rat model, the mycelium extract of (PLE) (20 mg/Kg) displayed significant protection against hepatic fibrosis. The present investigation characterized eleven new ionone derivatives, phellinulins D⁻N (⁻), from the mycelium extract and the relative stereochemical structures were constructed according to the spectroscopic and spectrometric analytical results. Some purified compounds were examined for their inhibitory effects on activated rat hepatic stellate cells (HSCs) and several isolates did exhibit significant protection. The results indicated that the mycelium of could be explored as a hepatoprotective drug or healthy food candidate in the near future.
在二甲基亚硝胺（DMN）诱导的肝纤维化 Wistar 大鼠模型中，（PLE）（20mg/Kg）菌丝体提取物对肝纤维化有显著的保护作用。本研究从 （PLE）菌丝体提取物中分离鉴定了 11 种新的薁酮衍生物（phellinulins D⁻N），根据光谱和光谱分析结果构建了相对立体化学结构。对一些纯化化合物进行了抑制激活的大鼠肝星状细胞（HSCs）的活性测试，发现一些分离物具有显著的保护作用。结果表明，在不久的将来，（PLE）的菌丝体可以作为一种保肝药物或保健品进行开发。
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