布鲁氏菌数据库：基因组信息资源。
BrucellaBase: Genome information resource.
作者信息
Sankarasubramanian Jagadesan, Vishnu Udayakumar S, Khader L K M Abdul, Sridhar Jayavel, Gunasekaran Paramasamy, Rajendhran Jeyaprakash
机构信息
Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai - 625021, Tamil Nadu, India.
Department of Genetics, School of Biological Sciences, Madurai Kamaraj University, Madurai - 625021, Tamil Nadu, India.
出版信息
Infect Genet Evol. 2016 Sep;43:38-42. doi: 10.1016/j.meegid.2016.05.006. Epub 2016 May 7.
Brucella sp. causes a major zoonotic disease, brucellosis. Brucella belongs to the family Brucellaceae under the order Rhizobiales of Alphaproteobacteria. We present BrucellaBase, a web-based platform, providing features of a genome database together with unique analysis tools. We have developed a web version of the multilocus sequence typing (MLST) (Whatmore et al., 2007) and phylogenetic analysis of Brucella spp. BrucellaBase currently contains genome data of 510 Brucella strains along with the user interfaces for BLAST, VFDB, CARD, pairwise genome alignment and MLST typing. Availability of these tools will enable the researchers interested in Brucella to get meaningful information from Brucella genome sequences. BrucellaBase will regularly be updated with new genome sequences, new features along with improvements in genome annotations. BrucellaBase is available online at http://www.dbtbrucellosis.in/brucellabase.html or http://59.99.226.203/brucellabase/homepage.html.
布鲁氏菌属引发一种主要的人畜共患病——布鲁氏菌病。布鲁氏菌属于变形菌门α-变形菌纲根瘤菌目下的布鲁氏菌科。我们展示了布鲁氏菌数据库（BrucellaBase），这是一个基于网络的平台，具备基因组数据库的功能以及独特的分析工具。我们开发了多基因座序列分型（MLST）的网络版本（Whatmore等人，2007年）以及布鲁氏菌属的系统发育分析。布鲁氏菌数据库目前包含510株布鲁氏菌的基因组数据，以及用于BLAST、VFDB、CARD、成对基因组比对和MLST分型的用户界面。这些工具的可用性将使对布鲁氏菌感兴趣的研究人员能够从布鲁氏菌基因组序列中获取有意义的信息。布鲁氏菌数据库将定期更新新的基因组序列、新功能以及基因组注释方面的改进。布鲁氏菌数据库可通过以下网址在线获取：http://www.dbtbrucellosis.in/brucellabase.html 或 http://59.99.226.203/brucellabase/homepage.html。
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