Swaney Kristen F, Li Rong
Department of Cell Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, 450 Rangos Building, Baltimore, MD 21205, USA; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, 3400 North Charles Street, 100 Croft Hall, Baltimore, MD 21218, USA.
Department of Cell Biology, Johns Hopkins University School of Medicine, 855 North Wolfe Street, 450 Rangos Building, Baltimore, MD 21205, USA; Department of Chemical and Biomolecular Engineering, Whiting School of Engineering, Johns Hopkins University, 3400 North Charles Street, 100 Croft Hall, Baltimore, MD 21218, USA.
Curr Opin Cell Biol. 2016 Oct;42:63-72. doi: 10.1016/j.ceb.2016.04.005. Epub 2016 May 8.
As the first de novo actin nucleator discovered, the Arp2/3 complex has been a central player in models of protrusive force production via the dynamic actin network. Here, we review recent studies on the functional role of the Arp2/3 complex in the migration of diverse cell types in different migratory environments. These findings have revealed an unexpected level of plasticity, both in how cells rely on the Arp2/3 complex for migration and other physiological functions and in the intricate modulation of the Arp2/3 complex by other actin regulators and upstream signaling cascades.
作为首个被发现的从头肌动蛋白成核因子,Arp2/3复合物一直是通过动态肌动蛋白网络产生突出力模型中的核心参与者。在此,我们综述了近期关于Arp2/3复合物在不同迁移环境中多种细胞类型迁移的功能作用的研究。这些发现揭示了意想不到的可塑性水平,既体现在细胞如何依赖Arp2/3复合物进行迁移和其他生理功能方面,也体现在其他肌动蛋白调节因子和上游信号级联对Arp2/3复合物的复杂调控方面。