Department of Immunology and Microbiology, University of Colorado School of Medicine Aurora, CO, USA.
Barbara Davis Research Center, University of Colorado School of Medicine, Aurora, CO, USA.
FEBS J. 2022 Oct;289(20):6154-6171. doi: 10.1111/febs.16130. Epub 2021 Aug 3.
During their life span, T cells are tasked with patrolling the body for potential pathogens. To do so, T cells migrate through numerous distinct anatomical sites and tissue environments with different biophysical characteristics. To migrate through these different environments, T cells use various motility strategies that rely on actin network remodeling to generate shape changes and mechanical forces. In this review, we initially discuss the migratory journey of T cells and then cover the actin polymerization effectors at play in T cells, and finally, we focus on the function of these effectors of actin cytoskeleton remodeling in mediating T-cell migration through diverse tissue environments. Specifically, we will discuss the current state of the field pertaining to our understanding of the roles in T-cell migration played by members of the three main families of actin polymerization machinery: the Arp2/3 complex; formin proteins; and Ena/VASP proteins.
在其生命周期中，T 细胞负责在体内巡逻以寻找潜在的病原体。为此，T 细胞通过具有不同生物物理特性的许多不同解剖部位和组织环境迁移。为了迁移到这些不同的环境中，T 细胞使用各种依赖于肌动蛋白网络重塑的运动策略来产生形状变化和机械力。在这篇综述中，我们首先讨论 T 细胞的迁移过程，然后介绍在 T 细胞中起作用的肌动蛋白聚合效应因子，最后，我们重点介绍肌动蛋白细胞骨架重塑的这些效应因子在介导 T 细胞通过不同组织环境迁移中的功能。具体来说，我们将讨论当前领域的现状，了解肌动蛋白聚合机制的三个主要家族成员在 T 细胞迁移中所起的作用：Arp2/3 复合物；formin 蛋白；和 Ena/VASP 蛋白。
