Yow L, Nelson J S, Berns M W
Beckman Laser Institute and Medical Clinic, University of California, Irvine 92715.
Lasers Surg Med. 1989;9(2):141-7. doi: 10.1002/lsm.1900090209.
One of the main problems in orthopaedics is the surgical removal of hard substances, such as bone and polymethylmethacrylate (PMMA). Such materials are often very difficult to remove without mechanical trauma to the remaining tissue. This study investigated the feasibility of the ultraviolet 308 nm excimer laser in the ablation of these materials. The beam was delivered through a 1 mm-diameter fiber optic at 40 Hz with energy densities at the target surface of 20-80 J/cm2 per pulse. The goal of the study was to establish the ideal dosimetry for removing bone and PMMA with minimum trauma to the adjacent tissue. Histology revealed that the 308 nm laser effectively removed bone leaving a thermal damage zone of only 2-3 microns in the remaining tissue. Increasing the energy per pulse gave correspondingly larger and deeper cuts with increasing zones of thermal damage. The excimer laser was also effective in the ablation of PMMA, creating craters in the substrate with a thermal damage zone of 10-40 microns. The debris from both substrates was evaluated.
骨科的主要问题之一是手术切除坚硬物质,如骨骼和聚甲基丙烯酸甲酯(PMMA)。在不对剩余组织造成机械损伤的情况下,这类材料往往很难切除。本研究调查了紫外线308纳米准分子激光消融这些材料的可行性。光束通过直径1毫米的光纤以40赫兹的频率传输,目标表面的能量密度为每脉冲20 - 80焦耳/平方厘米。该研究的目的是确定以对相邻组织造成最小创伤来去除骨骼和PMMA的理想剂量学。组织学显示,308纳米激光有效地去除了骨骼,在剩余组织中留下仅2 - 3微米的热损伤区。增加每脉冲的能量会相应地产生更大、更深的切口,同时热损伤区也会增加。准分子激光对PMMA的消融也有效,在基底上形成了热损伤区为10 - 40微米的凹坑。对两种基底的碎屑进行了评估。