血管升压素1a、2和1b受体选择性激动剂对大鼠肾脏钠转运的影响
Effects of Selective Agonists of V1a, V2, and V1b Receptors on Sodium Transport in Rat Kidney.
作者信息
Golosova D V, Karavashkina T A, Kutina A V, Marina A S, Natochin Yu V
机构信息
Laboratory of Renal Physiology and Water-Salt Balance, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
出版信息
Bull Exp Biol Med. 2016 Apr;160(6):751-4. doi: 10.1007/s10517-016-3301-x. Epub 2016 May 11.
The role of subtypes of vasopressin receptors in modulation of renal sodium reabsorption was studied in in vivo experiments on Wistar rats. Selective V1a receptor agonist reduced sodium reabsorption in the kidneys and expression of these receptors increased by practically 100 times. This effect was similar to the effect of furosemide. Selective V2 receptor agonist enhanced sodium reabsorption in the kidney and simultaneously increased reabsorption of solute-free water. Stimulation of V1b receptors did not affect sodium transport. Our findings attest to the key role of V1a receptors in the regulation of renal excretion of sodium ions.
在对Wistar大鼠进行的体内实验中，研究了血管加压素受体亚型在调节肾钠重吸收中的作用。选择性V1a受体激动剂降低了肾脏中的钠重吸收，这些受体的表达实际上增加了100倍。这种作用与呋塞米的作用相似。选择性V2受体激动剂增强了肾脏中的钠重吸收，同时增加了无溶质水的重吸收。刺激V1b受体不影响钠转运。我们的研究结果证明了V1a受体在调节肾钠离子排泄中的关键作用。
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