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依托咪酯作为危重症患者麻醉诱导药物的作用。

The role of etomidate as an anaesthetic induction agent for critically ill patients.

作者信息

Allen Claire, Washington Stephen

机构信息

ST6 in Anaesthesia in the Department of Anaesthesia, University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT.

Consultant Anaesthetist in the Department of Anaesthesia, University Hospital of South Manchester NHS Foundation Trust, Manchester.

出版信息

Br J Hosp Med (Lond). 2016 May;77(5):282-6. doi: 10.12968/hmed.2016.77.5.282.

DOI:10.12968/hmed.2016.77.5.282
PMID:27166106
Abstract

Etomidate is an anaesthetic induction agent which may be favoured in critically ill patients because of its cardiovascular stability. However, etomidate causes adrenocortical suppression which may be particularly harmful in these patients. This article reviews current evidence and debates the use of etomidate in critical illness.

摘要

依托咪酯是一种麻醉诱导剂,由于其心血管稳定性,可能更受重症患者青睐。然而,依托咪酯会导致肾上腺皮质抑制,这对这些患者可能特别有害。本文综述了当前证据,并对依托咪酯在危重病中的应用进行了讨论。

相似文献

1
The role of etomidate as an anaesthetic induction agent for critically ill patients.依托咪酯作为危重症患者麻醉诱导药物的作用。
Br J Hosp Med (Lond). 2016 May;77(5):282-6. doi: 10.12968/hmed.2016.77.5.282.
2
Novel etomidate derivatives.新型依托咪酯衍生物。
Curr Pharm Des. 2012;18(38):6253-6. doi: 10.2174/138161212803832362.
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Etomidate for critically ill patients. Pro: yes we can use it.依托咪酯在危重症患者中的应用。赞成:可以用。
Eur J Anaesthesiol. 2012 Nov;29(11):506-10. doi: 10.1097/EJA.0b013e32835819b0.
4
Adrenocortical function in critically ill patients 24 h after a single dose of etomidate.单次给予依托咪酯24小时后危重症患者的肾上腺皮质功能。
Anaesthesia. 1999 Sep;54(9):861-7. doi: 10.1046/j.1365-2044.1999.01003.x.
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Etomidate as an Induction Agent in Sepsis.依托咪酯作为脓毒症的诱导剂。
Crit Care Nurs Clin North Am. 2018 Sep;30(3):e1-e9. doi: 10.1016/j.cnc.2018.05.004. Epub 2018 Jul 13.
6
Etomidate versus ketamine as an induction agent for intubation in critically ill patients: A systematic review and meta-analysis.依托咪酯与氯胺酮作为危重症患者气管插管诱导药物的比较:一项系统评价与荟萃分析
Asian J Surg. 2024 Oct;47(10):4374-4376. doi: 10.1016/j.asjsur.2024.07.142. Epub 2024 Aug 10.
7
Should etomidate be used for rapid-sequence intubation induction in critically ill septic patients? Probably not.对于重症脓毒症患者,依托咪酯是否应用于快速顺序诱导插管?可能不行。
Am J Emerg Med. 2008 Jul;26(6):728-9; author reply 729-30. doi: 10.1016/j.ajem.2008.04.010.
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Should etomidate be used for rapid-sequence intubation induction in critically ill septic patients?对于重症脓毒症患者,依托咪酯是否应用于快速序贯诱导插管?
Am J Emerg Med. 2008 Feb;26(2):229-32. doi: 10.1016/j.ajem.2007.03.032.
9
Clinical and molecular pharmacology of etomidate.依托咪酯的临床与分子药理学。
Anesthesiology. 2011 Mar;114(3):695-707. doi: 10.1097/ALN.0b013e3181ff72b5.
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Etomidate enabled electroconvulsive therapy without suppressing adrenocortical function in a case with difficulties in inducing seizures by conventional methods.依托咪酯使电休克治疗在一例采用传统方法诱导癫痫发作困难的病例中得以实施,且未抑制肾上腺皮质功能。
Psychiatry Clin Neurosci. 2020 Nov;74(11):624-626. doi: 10.1111/pcn.13139. Epub 2020 Sep 17.

引用本文的文献

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Optimizing sedation in gastroscopy: a study on the etomidate/propofol mixture ratio.优化胃镜检查中的镇静:依托咪酯/丙泊酚混合比例的研究
Front Med (Lausanne). 2024 Jun 12;11:1392141. doi: 10.3389/fmed.2024.1392141. eCollection 2024.
2
Oxidative stress under general intravenous and inhalation anaesthesia.全身静脉和吸入麻醉下的氧化应激。
Arh Hig Rada Toksikol. 2020 Oct 6;71(3):169-177. doi: 10.2478/aiht-2020-71-3437. Print 2020 Sep 1.
3
A randomized clinical trial comparing hemodynamic responses to ketamine-propofol combination (ketofol) versus etomidate during anesthesia induction in patients with left ventricular dysfunction undergoing coronary artery bypass graft surgery.
一项随机临床试验,比较左心室功能不全患者在接受冠状动脉搭桥手术时,麻醉诱导期氯胺酮 - 丙泊酚合剂(氯胺酚)与依托咪酯的血流动力学反应。
Arch Med Sci. 2017 Aug;13(5):1102-1110. doi: 10.5114/aoms.2016.63193. Epub 2016 Oct 25.
4
Effect of etomidate on the oxidative stress response and levels of inflammatory factors from ischemia-reperfusion injury after tibial fracture surgery.依托咪酯对胫骨骨折手术后缺血再灌注损伤的氧化应激反应及炎症因子水平的影响。
Exp Ther Med. 2017 Mar;13(3):971-975. doi: 10.3892/etm.2017.4037. Epub 2017 Jan 12.