Hoai Nguyen Thi, Duc Ho Viet, Phu Nguyen Dinh Quynh, Kodama Takeshi, Itob Takuya, Morita Hiroyuki
Nat Prod Commun. 2016 Mar;11(3):365-7.
A new iridoid, 10-acetylborreriagenin (1), and five known iridoid glycosides (2-6), were isolated from the aerial parts of Hedyotis pilulifera. Their structures were elucidated by spectral analyses, including 1D- and 2D-NMR, and HR-ESI-MS, and comparisons with the NMR data reported in the literature. The isolated compounds 1-6 were tested against six bacterial species. Among them, 10-acetylborreriagenin (1) showed antibacterial activity against Staphylococcus aureus, with an MIC value of 100 µg/mL.
从丸花耳草的地上部分分离得到一种新的环烯醚萜类化合物10-乙酰基车叶草苷元（1）和五种已知的环烯醚萜苷（2-6）。通过一维和二维核磁共振谱、高分辨电喷雾电离质谱等光谱分析，并与文献报道的核磁共振数据进行比较，确定了它们的结构。对分离得到的化合物1-6进行了六种细菌的测试。其中，10-乙酰基车叶草苷元（1）对金黄色葡萄球菌具有抗菌活性，最低抑菌浓度值为100μg/mL。
