Kirkpatrick D B
Utah Neurological Clinic, Provo.
Neurosurgery. 1989 May;24(5):758-61. doi: 10.1227/00006123-198905000-00018.
Trigeminal neuralgia in its classic form is usually an isolated disease that occurs in sporadic fashion without epidemiological or genetic significance. This paper discusses a family with three nontwin sisters, all of whom have classic trigeminal neuralgia occurring in early middle age with symptoms severe enough to require medical and surgical treatment. These three sisters also have one aunt with a history of severe facial pain, although this has not been medically documented. Clustering of such cases in a given family has been reported before, but is rare. The pathophysiological implications of this genetic clustering are discussed.
典型形式的三叉神经痛通常是一种孤立性疾病，呈散发性发生，无流行病学或遗传学意义。本文讨论了一个有三名非双胞胎姐妹的家庭，她们均患有典型的三叉神经痛，发病于中年早期，症状严重到需要药物和手术治疗。这三姐妹还有一位有严重面部疼痛病史的阿姨，不过这尚未得到医学记录。此前曾有报道称在特定家庭中出现此类病例聚集的情况，但很罕见。本文讨论了这种基因聚集的病理生理学意义。
