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疼痛与疼痛抑制的遗传学

The genetics of pain and pain inhibition.

作者信息

Mogil J S, Sternberg W F, Marek P, Sadowski B, Belknap J K, Liebeskind J C

机构信息

Department of Psychology, University of California, Los Angeles, 90095-1563, USA.

出版信息

Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):3048-55. doi: 10.1073/pnas.93.7.3048.

DOI:10.1073/pnas.93.7.3048
PMID:8610166
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC39759/
Abstract

The present review summarizes the current state of knowledge about the genetics of pain-related phenomena and illustrates the scope and power of genetic approaches to the study of pain. We focus on work performed in our laboratories in Jastrzebiec, Poland; Portland, OR; and Los Angeles, which we feel demonstrates the continuing usefulness of classical genetic approaches, especially when used in combination with newly available molecular genetic techniques.

摘要

本综述总结了目前关于疼痛相关现象遗传学的知识现状,并阐述了遗传学方法在疼痛研究中的范围和作用。我们重点关注在波兰亚斯切别茨、俄勒冈州波特兰和洛杉矶我们实验室所开展的工作,我们认为这些工作证明了经典遗传学方法的持续有效性,尤其是在与新出现的分子遗传学技术结合使用时。

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本文引用的文献

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Pain in Men Wounded in Battle.战斗中受伤男性的疼痛
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The optimal dose of morphine.吗啡的最佳剂量。
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Differential genetic mediation of sensitivity to morphine in genetic models of opiate antinociception: influence of nociceptive assay.阿片类镇痛遗传模型中吗啡敏感性的差异基因介导:伤害性检测的影响
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Antagonism of the non-opioid component of ethanol-induced analgesia by the NMDA receptor antagonist MK-801.NMDA受体拮抗剂MK-801对乙醇诱导镇痛的非阿片类成分的拮抗作用。
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Evidence for the up-regulation of kappa opiate mechanisms in mice selectively bred for high analgesia.在为高镇痛能力而选择性培育的小鼠中κ阿片机制上调的证据。
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8
Introduction of a point mutation into the mouse genome by homologous recombination in embryonic stem cells using a replacement type vector with a selectable marker.利用带有选择标记的置换型载体,通过胚胎干细胞中的同源重组将点突变引入小鼠基因组。
Nucleic Acids Res. 1993 Jun 11;21(11):2613-7. doi: 10.1093/nar/21.11.2613.
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Independent expression of two pharmacologically distinct supraspinal mu analgesic systems in genetically different mouse strains.两种药理学上不同的脊髓上μ阿片镇痛系统在基因不同的小鼠品系中的独立表达。
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Morphine-induced place preference in the CXBK mouse: characteristics of mu opioid receptor subtypes.CXBK小鼠中吗啡诱导的位置偏爱:μ阿片受体亚型的特征
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