Jagelavičienė Eglė, Krasauskienė Aurelija, Žalinkevičius Rimantas, Vaitkevičienė Inga, Kubilius Ričardas
Department of Dental and Oral Pathology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Department of Endocrinology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Medicina (Kaunas). 2016;52(2):125-31. doi: 10.1016/j.medici.2016.02.005. Epub 2016 Mar 11.
In clinical practice, a comparative analysis of bone mineral density (BMD) is carried out by examining different skeletal bones. This is useful for screening of postmenopausal osteoporosis (OP). The objective of this study was to determine the relation between the mandibular cortical index (MCI) and calcaneal BMD among postmenopausal women.
The study sample included 129 randomly selected postmenopausal women aged 50-77 years. The participants were examined using panoramic radiography for the analysis of the cortical layer in the mandibular base for MCI determination and using DXL for the examination of calcaneal BMD. According to T scores, the subjects were divided into three groups (Groups 1, 2, and 3). The panoramic radiographic examination of the mandible was performed; the MCI was determined and distributed into groups (C1; C2; C3). The MCI validity in determining the calcaneus BMD status was analyzed.
The differences in BMD were statistically significant between Groups C1 and C3 (P<0.01), Groups C2 and C3 (P=0.01), and between the calcaneal BMD groups (P<0.001). There was a statistically significant inverse correlation between the MCI and calcaneal BMD (r=-0.3; P<0.001). The changes characteristic of Group C2 were documented more frequently than those of other morphological groups. The analysis of the MCI validity in BMD status showed low sensitivity (69.4%) and specificity (53.9%).
The relation between MCI and calcaneal BMD was determined. The diagnostic discrimination of the MCI was found to be not sufficient in screening the women with postmenopausal osteoporosis and its application in clinical practice might be limited.
在临床实践中,通过检查不同骨骼来进行骨密度(BMD)的比较分析。这对于绝经后骨质疏松症(OP)的筛查很有用。本研究的目的是确定绝经后女性下颌骨皮质指数(MCI)与跟骨骨密度之间的关系。
研究样本包括129名年龄在50 - 77岁之间随机选取的绝经后女性。参与者接受全景X线摄影以分析下颌骨基部皮质层来确定MCI,并使用双能X线吸收法(DXL)检查跟骨骨密度。根据T值,将受试者分为三组(第1、2和3组)。对下颌骨进行全景X线摄影检查;确定MCI并分组(C1;C2;C3)。分析MCI在确定跟骨骨密度状态方面的有效性。
C1组与C3组之间、C2组与C3组之间的骨密度差异具有统计学意义(P<0.01),跟骨骨密度组之间差异具有统计学意义(P<0.001)。MCI与跟骨骨密度之间存在统计学意义的负相关(r = -0.3;P<0.001)。C2组的特征性变化比其他形态学组更频繁地被记录到。MCI在骨密度状态方面的有效性分析显示敏感性低(69.4%)和特异性低(53.9%)。
确定了MCI与跟骨骨密度之间的关系。发现MCI在筛查绝经后骨质疏松症女性时诊断鉴别能力不足,其在临床实践中的应用可能有限。