（-）-表没食子儿茶素-3-没食子酸酯（EGCG）减轻大鼠砷诱导的心脏毒性。
(-)-Epigallocatechin-3-gallate (EGCG) attenuates arsenic-induced cardiotoxicity in rats.
作者信息
Sun Tao-Li, Liu Zhi, Qi Zheng-Jun, Huang Yong-Pan, Gao Xiao-Qin, Zhang Yan-Yan
机构信息
Department of Pharmacology, Xiangnan College, Chenzhou, Hunan, 423000, China.
Department of Pharmacology, Guizhou Medical University, Guiyang, Guizhou, 550004, China; Department of Urology Surgery and Oncology, The Second Affiliated Hospital of Guizhou Medical University, Kaili, Guizhou, 556000, China; Department of Histology and Embryology, Guizhou Medical University, Guiyang, Guizhou, 550004, China.
出版信息
Food Chem Toxicol. 2016 Jul;93:102-10. doi: 10.1016/j.fct.2016.05.004. Epub 2016 May 8.
Chronic arsenic exposure in drinking water is associated with the abnormalities of cardiac tissue. Excessive generation of ROS induced by arsenic has a central role in arsenic-induced cardiotoxicity. (-)-Epigallocatechin-3-gallate (EGCG), the most abundant polyphenol in green tea, possesses a potent antioxidant capacity and exhibits extensive pharmacological activities. This study was aim to evaluate the effect of EGCG on arsenic-induced cardiotoxicity in vivo and in vitro. Treatment with NaAsO2 seriously affected the morphology and ultrastructure of myocardium, and induced cardiac injuries, oxidative stress, intracellular calcium accumulation and apoptosis in rats. In consistent with in vivo study, the injuries, oxidative stress and apoptosis were also observed in NaAsO2-treated H9c2 cells. All of these effects induced by NaAsO2 were attenuated by EGCG. These results suggest EGCG could attenuate NaAsO2-induced cardiotoxicity, and the mechanism may involve its potent antioxidant capacity.
饮用水中慢性砷暴露与心脏组织异常有关。砷诱导的活性氧过量生成在砷诱导的心脏毒性中起核心作用。（-）-表没食子儿茶素-3-没食子酸酯（EGCG）是绿茶中含量最丰富的多酚，具有强大的抗氧化能力，并表现出广泛的药理活性。本研究旨在评估EGCG在体内和体外对砷诱导的心脏毒性的影响。用NaAsO₂处理严重影响了大鼠心肌的形态和超微结构，并诱导了心脏损伤、氧化应激、细胞内钙积累和细胞凋亡。与体内研究一致，在NaAsO₂处理的H9c2细胞中也观察到了损伤、氧化应激和细胞凋亡。EGCG减弱了NaAsO₂诱导的所有这些效应。这些结果表明EGCG可以减轻NaAsO₂诱导的心脏毒性，其机制可能涉及其强大的抗氧化能力。
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