Meregalli M, Gambelli F, Torchio G, Bocchia M
Presidio Ospedaliero di Garbagnate Milanese, Divisione di Medicina Generale II.
Minerva Med. 1989 Mar;80(3):299-302.
Thrombocytopenic thrombotic purpura is a comparatively rare disease and little is known about its aetiopathogenesis. Once almost invariably negative, the prognosis has been changed by the introduction of plasmapheresis. A particularly complex clinical case is described and a number of conclusions are drawn from it: 1) there is no criterion for opting for any particular therapeutic approach; 2) evaluation of the clinical response is the only criterion for monitoring the effectiveness of ongoing treatment; 3) plasmapheresis is proposed as the treatment of choice; 4) vincristine is a useful alternative in the treatment of recalcitrant cases.
血小板减少性血栓性紫癜是一种相对罕见的疾病，对其病因发病机制了解甚少。曾经几乎总是预后不良，血浆置换术的引入改变了这一状况。本文描述了一个特别复杂的临床病例，并从中得出了一些结论：1）没有选择任何特定治疗方法的标准；2）评估临床反应是监测正在进行的治疗效果的唯一标准；3）建议将血浆置换术作为首选治疗方法；4）长春新碱是治疗难治性病例的一种有用的替代方法。
