Hakanen T, Saha M T, Salo M K, Nummi T, Harjunmaa U, Lipiäinen L, Vuorela N
School of Health Sciences, University of Tampere, Tampere, Finland.
Tampere Center for Child Health Research, University of Tampere, Tampere University Hospital, Tampere, Finland.
Acta Paediatr. 2016 Oct;105(10):1166-72. doi: 10.1111/apa.13468. Epub 2016 Jun 8.
We tracked the body mass index (BMI) of children born to mothers with or without gestational diabetes mellitus (GDM) or type 1 diabetes from birth to 12 years of age and examined the trends in both diseases.
Antenatal and postnatal health survey data were collected from 6909 Finnish children born at six time points between 1974 and 2004. We compared the BMI trajectory between the offspring of mothers with and without GDM or type 1 diabetes, and the association between GDM and overweight offspring was analysed.
The prevalence of GDM and type 1 diabetes increased markedly over the study period. The BMI trajectory in the GDM or type 1 diabetes offspring differed significantly from the nondiabetic offspring. The timing of adiposity rebound occurred significantly earlier in the GDM (4.8 years) and type 1 diabetes (4.4 years) groups than the nondiabetic group (5.5 years). GDM offspring were more likely to be overweight at five, seven and 12 years of age (24.6%, 28.1%, 29.4%) than nondiabetic offspring (15.6%, 18.3%, 18.1%).
Children born to mothers with GDM were significantly more likely to be overweight at an early age than those born to nondiabetic mothers.
我们追踪了患有或未患有妊娠期糖尿病（GDM）或1型糖尿病的母亲所生子女从出生到12岁的体重指数（BMI），并研究了这两种疾病的发展趋势。
收集了1974年至2004年间六个时间点出生的6909名芬兰儿童的产前和产后健康调查数据。我们比较了患有和未患有GDM或1型糖尿病的母亲的后代之间的BMI轨迹，并分析了GDM与超重后代之间的关联。
在研究期间，GDM和1型糖尿病的患病率显著增加。GDM或1型糖尿病后代的BMI轨迹与非糖尿病后代有显著差异。GDM组（4.8岁）和1型糖尿病组（4.4岁）的肥胖反弹时间明显早于非糖尿病组（5.5岁）。与非糖尿病后代（15.6%、18.3%、18.1%）相比，GDM后代在5岁、7岁和12岁时超重的可能性更高（分别为24.6%、28.1%、29.4%）。
患有GDM的母亲所生子女在幼年时超重的可能性明显高于非糖尿病母亲所生子女。
